Ahvaz Jundishapur University of Medical Sciences (AJUMS), Vice Chancellor for Research and Technology.Jundishapur Journal of Oncology2423-64711120150320Primary Mediastinal Lymphoma; The trend of incidence has turned toward the adults!144918110.22118/jjo.2015.49181ENAbdolhadi JahanshahiAssociate Professor of Thoracic Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Seyed Mansour AlamshahAssociate Professor of General and Vascular Surgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Journal Article20140419Background: Thymoma, lymphoma and neurogenic tumors are accounted as common mediastinal masses. They are more common in youngsters and middle ages. Although, lymphoma is proved to be more common in children, in recent years in our territory, adult cases were more dominant in referrals than previous.<br />Material and methods: This retrospective review of incidence and pathologic types were performed during last seven years since May 2004. All the patients with mediastinal mass (MM) were admitted in the study with characters of age, sex, clinical manifestations, chest radiography and CT scanning and biopsy for histological results.<br />Result: A total number of 97 patients, with mediastinal involvement by primary masses, were contributed in this study. Biopsy was taken through the several ways. The numbers of 52(53.60%) “Lymphoma” and 45 (46.40%) cases with other pathologic results were dominantly detected with “tuberculosis”. Two cases of lymphoma was found in two referred cases with MMs Conclusion: Conclusively most of MMs were located in the anterior mediastinum and about more than half of them were lymphoma as the most common malignant histological result. Since, preference of adult involvement was sta-tistically approved, we presumed that incidence of involvement is being turn towards adults in our territory and believe that it has been affected by some effective external factors such as mediastinal tuberculosis which was the second most mediastinal pathology.https://jjo.ajums.ac.ir/article_49181_c4d58bb3fd4e3a8a766cd05d98e82a10.pdfAhvaz Jundishapur University of Medical Sciences (AJUMS), Vice Chancellor for Research and Technology.Jundishapur Journal of Oncology2423-64711120150320Evaluation of correlation between the expression of p53 as a immunohistochemical marker&prognosis of gastric cancer584918210.22118/jjo.2015.49182ENNastaran RanjbariAssistant Professor of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences,Neda HojatpanahMD, Resident of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Journal Article20140410Background: Gastric cancer is the most common form of gastro intestinal malignancy in certain part of the word and the most common type is Adenocarcinoma. The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression. Therefore in this study, we investigate p53 expression in gastric cancer specimens and possible relationship between this marker and clinical-pathological factors of disease.<br />Material and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under-went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.<br />Result: P53 marker was positive in 40 cases (%74) of all cases. Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlate with vas-cular and neural invasion or involvement of margins.<br />Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua-tion of p53 level could be a useful tool in identification of patients with more aggressive disease.https://jjo.ajums.ac.ir/article_49182_b3cc2d279b557b56c8209a9b4cf3a8c4.pdfAhvaz Jundishapur University of Medical Sciences (AJUMS), Vice Chancellor for Research and Technology.Jundishapur Journal of Oncology2423-64711120150320Histological Subtype and Stage Study of Lung Cancers in Patients Referred to Radiotherapy and Oncology Department from Ahvaz Golestan Hospital for the duration of 2001-20119164918310.22118/jjo.2015.49183ENSeyed Mohammad HosseiniAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Sasan RazmjooAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranNasibeh NoshadiMedical Student, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Sholeh ArvandiAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranHodjatolah ShahbazianAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranJournal Article20140510Background: Lung cancer is the main leading cause of cancer deaths in men and the second leading cause of cancer death for women in worldwide. This study, explains the subtypes histological study of lung cancers in patients admitted to Ahvaz Golestan Hospital.<br />Material and methods: Data from the records of all patients with primary lung cancer that their disease was diag-nosed during the years of 2001 to 2011 were collected and coded to be analyzed by SPSS software version 20.<br />Result: Over the 11-year of study a total number of 483 lung cancer cases were identified. Of which, 13% were SCLC and 64.4% NSCLC. A total number of 141 of the patients were female and 372 male. The most common subtype among men was SCC while adenocarcinoma was the most frequent subtype among women. The mean age of pa-tients with SCLC, 63.16 years and in the case of NSCLC was 63 years.<br />Conclusion: The obtained results from this study showed that there was not a significant relationship for the pro-cess of changing in the subtype’s frequency, the male and female sex ratio as well as the mean age of patients.https://jjo.ajums.ac.ir/article_49183_5b44be11902ab6373604680454f18411.pdfAhvaz Jundishapur University of Medical Sciences (AJUMS), Vice Chancellor for Research and Technology.Jundishapur Journal of Oncology2423-64711120150320evaluation of 2 and 5 years survival rate of breast cancer in patients raffered to radiothrapy ward of Ahvaz Golestan hospital in 2001-200717204918410.22118/jjo.2015.49184ENSeyed Mohammad HosseiniAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Hojjattollah ShahbazianAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranAkram JaliliMedical Student, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSholeh ArvandiAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Sasan RazmjooAssistant professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Journal Article20140614Background: Cancers are in to accounted as chronic diseases that in many countries for recent decades have high rates of mortality. One of the most common cancers is breast cancer which is the second leading cause of cancer death in women after lung cancer. This study was performed to examine the 2-year and 5-year survival rate in pa-tients with metastatic breast cancer referring to Ahvaz Golestan Hospital Radiotherapy and oncology Department for the period of 2001-2007.<br />Material and methods: This study was a retrospective investigation and the studied population was the patients who had been hospitalized with breast cancer in Ahvaz Golestan Hospital Radiotherapy and oncology Department. The duration of patients’ survival rate was evaluated by obtaining the data from the archives, records and tele-phone calls.<br />Results: In this study, a total number of 352 patients were studied for breast cancer. The most patients were in the age range of 40-49 years with the prevalence percentage of 38.6. The less than 2 year survival rate was 47%, 2-year survival rate of 41.5% and 5-year survival rate of 11.5%, respectively. The frequency percentage of bone metastasis only was 40.3% however; the 59.7% was recorded for visceral metastasis.<br />Conclusion: Given the study results the survival rate of patients with over time was fewer so that, with 2-fold time, the survival rate was decreased to about one third to one quarter. In addition, the incidence of bone metastasis was associated with a better prognosis.https://jjo.ajums.ac.ir/article_49184_0c1d49539689c3a9166fd90a7d5ba43e.pdfAhvaz Jundishapur University of Medical Sciences (AJUMS), Vice Chancellor for Research and Technology.Jundishapur Journal of Oncology2423-64711120150320Neoadjuvant Chemotherapy in Local Advanced Gastric Cancer21244918510.22118/jjo.2015.49185ENJournal Article20140610dence in western countries. Surgery alone has not been effective for treatment of locoregional gastric cancer be-cause of the low rate of curative resection and high incidence of local recurrence and distant metastases. Our aim was to determine the resectability of tumor after neoadjuvant chemotherapy. Fourteen patients with clinical stage III gastric adenocarcinoma that initially seemed to be unresectable by laparoscopy were treated with three cycles of cisplatin 60 mg/m2, 5-Fluorouracil 750 mg/m2 and Epirubicin 50 mg/m2 three weeks before surgery. : Thirteen patients were operable for surgery after neoadjuvant chemotherapy (Pvalue= 0.001), while one patient was not operable due to developing distal metastasis. Twelve (85.85%) patients were resectable with patho-logic report of R 0 and, one (7.15%) patient was reported R1, (Pvalue= 0.001). A total number of 97 patients, with mediastinal involvement by primary masses, were contributed in this study. Biopsy was taken through the several ways. The numbers of 52(53.60%) “Lymphoma” and 45 (46.40%) cases with other pathologic results were dominantly detected with “tuberculosis”. Two cases of lymphoma was found in two referred cases with MMs <10 years and the overall incidence of involvement was begun from first to fifth dec-ades with the peak in third to fourth decades along with mostly anterior mediastinal locations. This study shows that neoadjuvant chemotherapy improves operability and resectability of the tumor in patients with local advanced gastric adenocarcinoma.https://jjo.ajums.ac.ir/article_49185_72f67c3a3bc5c525118ffeeaf5940d59.pdfAhvaz Jundishapur University of Medical Sciences (AJUMS), Vice Chancellor for Research and Technology.Jundishapur Journal of Oncology2423-64711120150320Congenital nasopharyngeal teratoma (epignathus) with airway obstruction25274918610.22118/jjo.2015.49186ENNastaran RanjbariAssistant Professor of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranAnahita Doustkhah VajariResident of Pathology, Department Of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Vita DerakhshandehResident of Pathology, Department Of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Journal Article20140419Introduction: Teratomas of the nasopharynx are rare in neonates, usually presenting in the neonatal period with frequency of the total 1 in 4000 live birth and derived from the upper jaw, palate and sphenoid bone. It usually protrudes through the mouth, leading to obstruction of the upper airway .Teratoma of the head and neck are most-ly benign neoplasm. In this article we are reporting a case of Epignathus associated with airway obstruction.<br />Case report: A 40 day old male neonate was admitted with severe respiratory distress and nasopharyngeal mass protrude to the oral cavity prevented oral feeding. History of mild hydroaminious was positive. No other abnormali-ties were noted on physical examination. MRI of the head and neck revealed solid cystic mass with nasopharyngeal origin without intracranial extension. Mass was resected surgically and pathology revealed a mature teratoma dom-inantly composed of mature neuroglial elements and choroid plexus. Nasopharyngeal teratoma cases are interesting because of their obscure origin and unusual clinical presentation.surgical resection is the treatment of choice and should be done urgently in the case of airway ob-struction.https://jjo.ajums.ac.ir/article_49186_79ffa418f8346811ea6b31efc7a5d9db.pdf