Frequency of histological subtypes and patients’ survival with tumors originating from thymus

Document Type : Original Article

Authors

1 Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background and Objective: Thymoma is a rare tumor in the mediastinum. Due to the fact that a complete study has not been conducted on thymoma in Khuzestan region, this study was designed as part of a comprehensive study on thymoma in Ahvaz Golestan Hospital.
Materials and Methods: This retrospective study was conducted on patients’ medical records with Thymoma attending Department of Radiotherapy and Oncology, Ahvaz Golestan Hospital, in a 10-year period from 2001 to 2011. The study also aimed to investigate the epidemiological data; diagnosis and treatment of patients for the duration of the same time.
Results: Among the 26 patients with a mean age of 45.38±SE, ratio of male to female was 5.5 to 1. The majority of the patients were in the range of 30-50 years old which jointly was at 61.8±SE. However, the minimum rate of tumor was seen in decades of 51-60 and 71-80 (7.7 %). In total, 72.7% (n=19) patients had invasive thymoma, while 27.3% (n=8) had noninvasive tumor. In addition, there was a significant relationship between invasive thymoma rate and developing myasthenia gravis. The 3-year survival rate for all patients was equivalent to 83.3%. However; 5-year survival was equal to 71%.
Conclusions: According to the study, most patients with invasive thymoma had a 5-year survival rate and also most of them were with myasthenia gravis.

Highlights

Seyed Mohammad Hosseini (PubMed)(Google Scholar)

Keywords

References

1. Hung AY, Eng TY, Scarbrough TJ, Dave Fuller C, Charles Rand Thomas Jr. Mediastinum and trachea In: Halprin, Edward C, pe-rez, Carlos A, Brady, Luther w, perez and brady s principles and practice of radiation oncology. 5th edition. philadelphia: hip-pincott, Williams and wilkins. 2008; 49:1-39.
2. Kondo K, Kinoshita H, Ishikura H, Miyoshi T, Hirose T, Matsu-mori Y, et al. Activation of matrix metalloproteinase‐2 is correlat-ed with invasiveness in thymic epithelial tumors. J Surgical Oncol. 2001; 76(3): 169-175.
3. Willcox N, Schluep M, Ritter A, Schuan JH, Newsom-Davis J, Chris-tensson B. Myasthenic and non myasthenic thymoma .AR expan-sion of minor cortical epithelial cell. Am J Pathol. Japanese and cross medical center. 2008; 58(8):489-493.
4. Keditsu KK, Karimundackal G, Jambhekar NA, Pramesh CS. Unu-sual clinical behavior of thymoma with recurrent myasthenia gravis. Interact Cardiovasc Thorac Surg. 2012; 14(6): 909-911.
5. Gommes DR, Fuller CD, Chennupati S, Charles R, Thomas Jr. Mediastinal and trachea in Halprin, Edward C, perez, carlos A, Brady Luther W, perez and Brady s principles and practice of radi-ation oncology 6th edition. philadelphia: Lippincott Williams & wilkins. 2013; 52:977-984.
6. Engels EA, Pfeiffer RM. Malignant thymoma in the United States: demographic patterns in incidence and associations with subse-quent malignancies. Int J Cancer. 2003; 105(4): 546-551.
7. Mao ZF, Mo XA, Qin C, Lai YR, Hackett ML. Incidence of thymoma in myasthenia gravis: a systematic review. Journal of Clinical Neu-rology. 2012; 8(3): 161-169.
8. McCart JA, Gaspar L, Inculet R, Casson AG. Predictors of survival following surgical resection of thymoma. Eur J Surg Oncol. 1993; 54(4):233-238.
9. Wilkins KB, Sheikh E, Green R, Patel M, George S, Takan M, et al. Clinical and pathologic predictors of survival in patients with thymoma. Ann Surg. 1999; 230(4): 562.
10. Margaritora S, Cesario A, Cusumano G, Meacci E, D'Angelillo R, Bonassi S, et al. Thirty-five–year follow-up analysis of clinical and pathologic outcomes of thymoma surgery. Ann Thorac Surg. 2010; 89(1):245-252.
11. Nakagawa K, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, et al. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardi-ovasc Surg. 2003; 126(4): 1134-1140.
12. Singhal BS, Bhatia NS, Umesh T, Menon S. A study from india in department of neurology bombey hospital institute of medical science. Neurol India. 2008; 56(3):352-5
13. Aysal F, Baybas S, Selçuk HH, Sozmen V, Ozturk M, Kucukoglu H, et al. Paraneoplastic extralimbic encephalitis associated with thymoma and myastenia gravis: Three years follow up. Clin Neu-rol Neurosurg. 2013; 115(5): 628-631.

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History

  • Receive Date: 22 June 2015
  • Revise Date: 10 October 2015
  • Accept Date: 05 November 2015

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