TY - JOUR ID - 49182 TI - Evaluation of correlation between the expression of p53 as a immunohistochemical marker&prognosis of gastric cancer JO - Jundishapur Journal of Oncology JA - JJO LA - en SN - 2423-6471 AU - Ranjbari, Nastaran AU - Hojatpanah, Neda AD - Assistant Professor of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences,􀀃􀀤􀁋􀁙􀁄􀁝􀀏􀀃􀀬􀁕􀁄􀁑􀀑􀀃 AD - MD, Resident of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Y1 - 2015 PY - 2015 VL - 1 IS - 1 SP - 5 EP - 8 KW - p53 KW - adenocarcinoma KW - immunohistochemical staining DO - 10.22118/jjo.2015.49182 N2 - Background: Gastric cancer is the most common form of gastro intestinal malignancy in certain part of the word and the most common type is Adenocarcinoma. The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression. Therefore in this study, we investigate p53 expression in gastric cancer specimens and possible relationship between this marker and clinical-pathological factors of disease.Material and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under-went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.Result: P53 marker was positive in 40 cases (%74) of all cases. Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlate with vas-cular and neural invasion or involvement of margins.Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua-tion of p53 level could be a useful tool in identification of patients with more aggressive disease. UR - https://jjo.ajums.ac.ir/article_49182.html L1 - https://jjo.ajums.ac.ir/article_49182_b3cc2d279b557b56c8209a9b4cf3a8c4.pdf ER -