The Association between H. pylori Antibodies as a Risk of Gastric Cancer, and Vitamin D Levels

Document Type : Original Article


1 Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, Iran

2 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran




Background: Helicobacter pylori (H. pylori) infection is known to be a major cause of chronic gastritis. Various studies have reported a link between H. pylori and vitamin D levels. Most of them showed the effect of serum levels of 25‐hydroxy‐vitamin D (25[OH]D) on the eradication of H. pylori infection. In the present study, we aimed to assess the association between serum levels of vitamin D and various type of antibodies against H. pylori infection. It is well recognized that H. pylori infection is the most important risk factor for gastric adenocarcinoma. Furthermore, vitamin D deficiency may be associated with a poor prognosis in gastric cancer.

Materials and Methods: In the present study, the medical records of randomly individuals who referred for screening to the Negaresh pathobiology laboratory in Tehran, Iran during 2019 to 2021, were retrospectively reviewed. 196 subjects were eligible for evaluation and enrolled. The serum concentration of Vitamin D was determined quantitatively via fully automated enzyme-linked immunosorbent assay (ELISA), as well as H. pylori IgG, IgM and IgA antibodies were analyzed quantitatively by using the ELISA microplate reader.

Results: According to our results, the serum levels of 25(OH)D did not change significantly in different groups of patients with different levels of H. pylori IgG, IgM and IgA antibodies.

Conclusion: The relationship between vitamin D and H. pylori remains to be determined. In conclusion, no significant relationship was identified between the level of vitamin D and the amount of different anti-H pylori antibodies, including IgG, IgM and IgA.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 06 March 2022
  • Receive Date: 04 December 2021
  • Revise Date: 21 February 2022
  • Accept Date: 06 March 2022