The Association Between H. pylori Antibodies as a Risk of Gastric Cancer and Vitamin D Levels

Document Type : Original Article


1 Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, Iran

2 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran



Objectives: Helicobacter pylori (H. pylori) infection is a significant cause of chronic
gastritis. Various studies have reported a link between H. pylori and vitamin D levels. Most
showed the effect of serum levels of 25 hydroxy vitamin D (25[OH]D) on the eradication
of H. pylori infection. In the present study, we aimed to assess the association between
vitamin D serum levels and various types of antibodies against H. pylori infection. It
is well recognized that H. pylori infection is the most important risk factor for gastric
adenocarcinoma. Furthermore, vitamin D deficiency may be associated with a poor
prognosis in gastric cancer.
Methods: In the present laboratory-based retrospective study, the medical records of
random individuals referred for screening to the Negaresh Pathobiology Laboratory in
Tehran, Iran, from 2019 to 2021 were retrospectively reviewed. A total of 196 subjects
were eligible for evaluation and were enrolled. The serum concentration of Vitamin D
was determined quantitatively via a fully automated enzyme-linked immunosorbent assay
(ELISA), and H. pylori IgG, IgM, and IgA antibodies were analyzed quantitatively by
using the ELISA microplate reader.
Results: According to our results, the serum levels of 25(OH)D did not change significantly
in different groups of patients with different levels of H. pylori IgG, IgM, and IgA antibodies.
Discussion: The relationship between vitamin D and H. pylori remains to be determined.
In conclusion, no significant relationship was identified between the level of vitamin D and
the amount of different anti-H pylori antibodies, including IgG, IgM, and IgA.


Mehrdad Haghighi (PubMed)(Google Scholar)

Reza Ghanbari (PubMed)(Google Scholar)


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