The Association Between H. pylori Antibodies as a Risk of Gastric Cancer and Vitamin D Levels

Document Type : Original Article

Authors

1 Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, Iran

2 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

10.32598/jjo.20.2.3

Abstract

Objectives: Helicobacter pylori (H. pylori) infection is a significant cause of chronic
gastritis. Various studies have reported a link between H. pylori and vitamin D levels. Most
showed the effect of serum levels of 25 hydroxy vitamin D (25[OH]D) on the eradication
of H. pylori infection. In the present study, we aimed to assess the association between
vitamin D serum levels and various types of antibodies against H. pylori infection. It
is well recognized that H. pylori infection is the most important risk factor for gastric
adenocarcinoma. Furthermore, vitamin D deficiency may be associated with a poor
prognosis in gastric cancer.
Methods: In the present laboratory-based retrospective study, the medical records of
random individuals referred for screening to the Negaresh Pathobiology Laboratory in
Tehran, Iran, from 2019 to 2021 were retrospectively reviewed. A total of 196 subjects
were eligible for evaluation and were enrolled. The serum concentration of Vitamin D
was determined quantitatively via a fully automated enzyme-linked immunosorbent assay
(ELISA), and H. pylori IgG, IgM, and IgA antibodies were analyzed quantitatively by
using the ELISA microplate reader.
Results: According to our results, the serum levels of 25(OH)D did not change significantly
in different groups of patients with different levels of H. pylori IgG, IgM, and IgA antibodies.
Discussion: The relationship between vitamin D and H. pylori remains to be determined.
In conclusion, no significant relationship was identified between the level of vitamin D and
the amount of different anti-H pylori antibodies, including IgG, IgM, and IgA.

Keywords


[1] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman
D. Global cancer statistics. CA: A Cancer Journal For Clinicians.
2011; 61(2):69-90. [DOI:10.3322/caac.20107] [PMID]
[2] Kim SS, Ruiz VE, Carroll JD, Moss SF. Helicobacter pylori in
the pathogenesis of gastric cancer and gastric lymphoma.
Cancer Letters. 2011; 305(2):228-38. [DOI:10.1016/j.canlet.
2010.07.014] [PMID] [PMCID]
[3] Sgouras D, Tegtmeyer N, Wessler S. Activity and functional
importance of Helicobacter pylori virulence factors.
Helicobacter pylori in Human Diseases. 2019:35-56.
[DOI:10.1007/5584_2019_358] [PMID]
[4] Fontham ET, Ruiz B, Perez A, Hunter F, Correa P. Determinants
of Helicobacter pylori infection and chronic gastritis.
American Journal of Gastroenterology (Springer Nature).
1995; 90(7):1094-101. [Link]
[5] Jonaitis L, Pellicano R, Kupcinskas L. Helicobacter pylori
and nonmalignant upper gastrointestinal diseases. Helicobacter.
2018; 23:e12522. [DOI:10.1111/hel.12522] [PMID]
[6] Lu C, Yu Y, Li L, Yu C, Xu P. Systematic review of the
relationship of Helicobacter pylori infection with geographical
latitude, average annual temperature and average
daily sunshine. BMC Gastroenterology. 2018; 18(1):1-9.
[DOI:10.1186/s12876-018-0779-x] [PMID] [PMCID]
[7] Bouillon R, Carmeliet G, Verlinden L, Van Etten E, Verstuyf
A, Luderer HF, Lieben L, Mathieu C, Demay M.
Vitamin D and human health: Lessons from vitamin D
receptor null mice. Endocrine Reviews. 2008; 29(6):726-76.
[DOI:10.1210/er.2008-0004] [PMID] [PMCID]
[8] Yang L, He X, Li L, Lu C. Effect of vitamin D on Helicobacter
pylori infection and eradication: A meta‚Äźanalysis. Helicobacter.
2019; 24(5):e12655. [DOI:10.1111/hel.12655] [PMCID]
[9] Sugano K. Effect of Helicobacter pylori eradication on the
incidence of gastric cancer: A systematic review and metaanalysis.
Gastric Cancer. 2019; 22(3):435-45. [DOI:10.1007/
s10120-018-0876-0]
[10] Kwak JH, Paik JK. Vitamin D status and gastric cancer:
A cross-sectional study in Koreans. Nutrients. 2020;
12(7):2004. [DOI:10.3390/nu12072004]
[11] Vyas N, Companioni RC, Tiba M, Alkhawam H, Catalano
C, Sogomonian R, et al. Association between serum
vitamin D levels and gastric cancer: A retrospective chart
analysis. World Journal of Gastrointestinal Oncology. 2016;
8(9):688. [DOI:10.4251/wjgo.v8.i9.688]
[12] Ofman JJ, Etchason J, Fullerton S, Kahn KL, Soll AH.
Management strategies for Helicobacter pylori-seropositive
patients with dyspepsia: Clinical and economic consequences.
Annals of Internal Medicine. 1997; 126(4):280-91.
[DOI:10.7326/0003-4819-126-4-199702150-00004] [PMID]
[13] Sheu BS, Shiesh SC, Yang HB, Su IJ, Chen CY, Lin XZ.
Implications of Helicobacter pylori serological titer for the
histological severity of antral gastritis. Endoscopy. 1997;
29(01):27-30. [DOI:10.1055/s-2007-1004057] [PMID]
[14] Sim JG, Kim CJ, Seo JK. The value of Helicobacter pylori
IgG antibody in estimating the severity of gastritis in children.
Journal of Korean Medical Science. 1995; 10:329-33.
[DOI:10.3346/jkms.1995.10.5.329] [PMID] [PMCID]
[15] Yamamoto I, Fukuda Y, Mizuta T, Fukada M, Nishigami
T, Shimoyama T. Serum anti-Helicobacter pylori antibodies
and gastritis. Journal of Clinical Gastroenterology. 1995;
21:S164-8. [PMID]
[16] Uemura N, Okamoto S, Yamamoto S, Matsumura N,
Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection
and the development of gastric cancer. The New England
Journal of Medicine. 2001; 345(11):784-9. [DOI:10.1056/NEJMoa001999]
[PMID]
[17] Correa P. Human gastric carcinogenesis: A multistep
and multifactorial process—first American Cancer Society
award lecture on cancer epidemiology and prevention.
Cancer Research. 1992; 52(24):6735-40. [Link]
[18] Pan L, Matloob AF, Du J, Pan H, Dong Z, Zhao J, Feng
Y, Zhong Y, Huang B, Lu J. Vitamin D stimulates apoptosis
in gastric cancer cells in synergy with trichostatin A/sodium
butyrate-induced and 5-aza-2′-deoxycytidine-induced
PTEN upregulation. The FEBS Journal. 2010; 277(4):989-99.
[DOI:10.1111/j.1742-4658.2009.07542.x] [PMID]
[19] Polek TC, Weigel NL. Vitamin D and prostate
cancer. Journal of Andrology. 2002; 23(1):9-17.
[DOI:10.1002/j.1939-4640.2002.tb02596.x] [PMID]
[20] Holick MF. Vitamin D: Importance in the prevention of
cancers, type 1 diabetes, heart disease, and osteoporosis.
American Journal of Clinical Nutrition. 2004; 79(3):362-71.
[DOI:10.1093/ajcn/79.3.362] [PMID]
[21] Kerr JF, Winterford CM, Harmon BV. Apoptosis.
Its significance in cancer and cancer therapy.
Cancer. 1994; 73(8):2013-26. [DOI:10.1002/1097-
0142(19940415)73:83.0.CO;2-J]
[22] Kronsteiner B, Bassaganya-Riera J, Philipson C, Viladomiu
M, Carbo A, Abedi V, et al. Systems-wide analyses
of mucosal immune responses to Helicobacter pylori at the
interface between pathogenicity and symbiosis. Gut Microbes.
2016; 7(1):3-21. [DOI:10.1080/19490976.2015.11166
73] [PMID] [PMCID]
[23] Bagheri N, Salimzadeh L, Shirzad H. The role of T
helper 1-cell response in Helicobacter pylori-infection.
Microbial Pathogenesis. 2018; 123:1-8. [DOI:10.1016/j.micpath.
2018.06.033] [PMID]
[24] Sugano K, Tack J, Kuipers EJ, Graham DY, El-Omar EM,
Miura S, et al. Kyoto global consensus report on Helicobacter
pylori gastritis. Gut. 2015; 64(9):1353-67. [DOI:10.1136/
gutjnl-2015-309252] [PMID] [PMCID]
[25] Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu
MS, et al. Association between Helicobacter pylori eradication
and gastric cancer incidence: A systematic review and
meta-analysis. Gastroenterology. 2016; 150(5):1113-24. e5.
[DOI:10.1053/j.gastro.2016.01.028] [PMID]
[26] Sakitani K, Nishizawa T, Arita M, Yoshida S, Kataoka Y,
Ohki D, et al. Early detection of gastric cancer after Helicobacter
pylori eradication due to endoscopic surveillance.
Helicobacter. 2018; 23(4):e12503. [DOI:10.1111/hel.12503]
[PMID] [PMCID]
[27] Nishizawa T, Suzuki H. Mechanisms of Helicobacter
pylori antibiotic resistance and molecular testing. Frontiers
in Molecular Biosciences. 2014; 1:19. [DOI:10.3389/
fmolb.2014.00019] [PMID] [PMCID]
[28] Talley N, Kost L, Haddad A, Zinsmeister A. Comparison
of commercial serological tests for detection of Helicobacter
pylori antibodies. Journal of Clinical Microbiology. 1992;
30(12):3146-50. [DOI:10.1128/jcm.30.12.3146-3150.1992]
[PMID] [PMCID]
[29] Surmeli DM, Surmeli ZG, Bahsi R, Turgut T, Oztorun HS,
Atmis V, et al. Vitamin D deficiency and risk of Helicobacter
pylori infection in older adults: A cross-sectional study. Aging
Clinical and Experimental Research. 2019; 31(7):985-91.
[DOI:10.1007/s40520-018-1039-1] [PMID]
[30] El Shahawy MS, Hemida MH, El Metwaly I, Shady ZM.
The effect of vitamin D deficiency on eradication rates of
Helicobacter pylori infection. JGH Open. 2018; 2(6):270-5.
[DOI:10.1002/jgh3.12081] [PMID] [PMCID]
Volume 2, Issue 2 - Serial Number 4
December 2016
Pages 38-44
  • Receive Date: 13 September 2016
  • Revise Date: 21 September 2016
  • Accept Date: 11 October 2016
  • First Publish Date: 01 December 2016