Primary Mediastinal Lymphoma; The trend of incidence has turned toward the adults!

Document Type : Original Article


1 Associate Professor of Thoracic Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Associate Professor of General and Vascular Surgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


Background: Thymoma, lymphoma and neurogenic tumors are accounted as common mediastinal masses. They are more common in youngsters and middle ages. Although, lymphoma is proved to be more common in children, in recent years in our territory, adult cases were more dominant in referrals than previous.
Material and methods: This retrospective review of incidence and pathologic types were performed during last seven years since May 2004. All the patients with mediastinal mass (MM) were admitted in the study with characters of age, sex, clinical manifestations, chest radiography and CT scanning and biopsy for histological results.
Result: A total number of 97 patients, with mediastinal involvement by primary masses, were contributed in this study. Biopsy was taken through the several ways. The numbers of 52(53.60%) “Lymphoma” and 45 (46.40%) cases with other pathologic results were dominantly detected with “tuberculosis”. Two cases of lymphoma was found in two referred cases with MMs Conclusion: Conclusively most of MMs were located in the anterior mediastinum and about more than half of them were lymphoma as the most common malignant histological result. Since, preference of adult involvement was sta-tistically approved, we presumed that incidence of involvement is being turn towards adults in our territory and believe that it has been affected by some effective external factors such as mediastinal tuberculosis which was the second most mediastinal pathology.


1. Thomas W shields. Diagnostic investigation of mediasti-
nal masses, in: Shields TW, Locicero J, Ronald BP. . Washington, Philadelph-
ia, Lippincott Williams &Wilkins, 2005; , 2495-2499. 2. Nason KS, Maddaus MA, Luketich JD. Chest wall, lung, mediastinum, and pleura, in: F. Charles Brunicardi, Dana K. Anderson, Timothy R. Billiar, David L. Dunn, John G. Hunter, Jeffrey B. Matthews, Raphael E. Pollock. Shwartz’s Principles of surgery, 9th edition. Mc Graw Hill, 2010; , 568 – 577. 3. Stremmel C, Passlick B. Surgery of mediastinal tumors. Chirurg. 2008; (1):9-10, 12-7.
4. Jaggers J, Balsara K. Mediastinal masses in children. . 2004; (3):201-8.
5. Shrivastava CP, Devgarha S, Ahlawat V. Mediastinal tu-
mors: a clinicopathological analysis. . 2006; (2):102-4.
6. Bastos P, Magalhaes A, Fernandes G, Cruz MR, Saleiro S, Goncalves L, Pinon M. Primary cysts and tumors of the mediastinum. . 2007; (5):659-73. 7. Alizzi AM, Hemli JM, Diqer AM, Bidstrup B. Primary soli-
tary mediastinal mass lesions: a review of 37 cases. . 2006; (5):310-3. 8. Lam JC, Chui CH, Jacobsen AS, Tan Am, Joseph VT. When is a mediastinal mass is critical in a child? An analysis of 29 patients. . 2004; (3):180-
4. 9. Quint LE. Imaging of anterior mediastinal masses. Can-
cer imaging. 2007 ; :7 Spec No A: 556-62.
10. Drevelegas A, Palladas P, Scordalaki A. Mediastinal germ cell tumors: a radiologic- pathologic review. .
2001, (10):1925-32. 11. Espostito G. Diagnosis of mediastinal masses and prin-
ciples of surgical tactics and technique for their treat-
ment. . 1999; (2):54-60. 12. Liu M, Hou N, Song X, Yu DJ, Zhao P, Li XH. Pathologic diagnosis of core needle biopsies of the mediastinum. . 2004; (2):135-9.
13. Wood DE. Mediastinal germ cell tumors. . 2000; (4):278-89. 14. Von der Weid NX. Adult life after surviving lymphoma in childhood. . 2008; (4):339-45. 15. Dosios T, Kouskos E, Kyriakou V. Surgical management of mediastinal lesions. . 2006; (3)207-
12. 16. Totanarungroj K, Watcharaporn C, Muangman N. Helpful
CT findings for giving specific diagnosis of anterior me-
diatinal tumors. . 2010; (4):489-96. 17. Sonali Smith & Korst Van Besien. Diagnosis and treat-
ment of mediastinal lymphoma, in: Shields TW, Locicero J, Ronald BP. General thoracic surgery, 6th edition. Wash-
ington, Philadelphia. . 2005. , 2694-2702. 18. D’Andrilli A, Venuta F, Rendina EA. Surgical approaches for invasive tumors of the anterior mediastinum. . 2010; (2):265-284. 19. Tang YJ, Tang JY, Pan C, Xue HL, Chen J, Shen SH, Dong L, Zhou M, Wang YP, Gu LJ, Jiang H, Ye QD. Clinical
characteristics and treatment outcome of 36 cases with non- Hodgkin’s lymphoma arising from mediastinum in children. . 2009; (9):687-90.
  • Receive Date: 19 April 2014
  • Revise Date: 11 October 2014
  • Accept Date: 23 November 2014
  • First Publish Date: 20 March 2015