Evaluation of correlation between the expression of p53 as a immunohistochemical marker&prognosis of gastric cancer

Document Type : Original Article


1 Assistant Professor of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences,􀀃􀀤􀁋􀁙􀁄􀁝􀀏􀀃􀀬􀁕􀁄􀁑􀀑􀀃

2 MD, Resident of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


Background: Gastric cancer is the most common form of gastro intestinal malignancy in certain part of the word and the most common type is Adenocarcinoma. The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression. Therefore in this study, we investigate p53 expression in gastric cancer specimens and possible relationship between this marker and clinical-pathological factors of disease.
Material and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under-went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.
Result: P53 marker was positive in 40 cases (%74) of all cases. Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlate with vas-cular and neural invasion or involvement of margins.
Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua-tion of p53 level could be a useful tool in identification of patients with more aggressive disease.


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