Different Features of the Regulatory T Cells in Gastrointestinal Tract Cancers and Disorders

Document Type : Review Article


Shiraz Institute for Cancer research, Shiraz University of Medical Sciences,Shiraz Iran.


Introduction:Regulatory T cells (Treg) located in tissues have a critical role in controllinghomeostasis and immune responses also modulate non-immunological processes.The T cell receptor repertoires of non-lymphoid tissue Tregs are distinct from Tregs in lymphoid organs.Less information is available about various ways to change the program of transcription in tissue-resident subsets of Treg cellsfor adapting to very different fields. However, recent progress in our understanding of Treg cells that reside in two important sites, the gut and adipose tissue, may provide some clues. Gastrointestinal is the largest reservoir for tissue-resident Treg cells in the body. Adequate number and performance of intestinal Treg cells are essential for maintaining normal intestinal immune homeostasis.Regulatory T cells in the GI tract have shown conflicting features. Therefore, in this study, phenotypic and functional characteristics of Treg cells are discussed in normal conditions, chronic inflammatory bowel disease (IBD) and colorectal cancer (CRC), as well as Treg cell therapeutic strategies in the treatment of these diseases.


Marziye Norozian (PubMed)(Google Scholar)

Abbas Ghaderi (PubMed)(Google Scholar)



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