Frequency of histological subtypes and patients’ survival with tumors originating from thymus

Document Type : Original Article


1 Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Tehran University of Medical Sciences, Tehran, Iran


Background and Objective: Thymoma is a rare tumor in the mediastinum. Due to the fact that a complete study has not been conducted on thymoma in Khuzestan region, this study was designed as part of a comprehensive study on thymoma in Ahvaz Golestan Hospital.
Materials and Methods: This retrospective study was conducted on patients’ medical records with Thymoma attending Department of Radiotherapy and Oncology, Ahvaz Golestan Hospital, in a 10-year period from 2001 to 2011. The study also aimed to investigate the epidemiological data; diagnosis and treatment of patients for the duration of the same time.
Results: Among the 26 patients with a mean age of 45.38±SE, ratio of male to female was 5.5 to 1. The majority of the patients were in the range of 30-50 years old which jointly was at 61.8±SE. However, the minimum rate of tumor was seen in decades of 51-60 and 71-80 (7.7 %). In total, 72.7% (n=19) patients had invasive thymoma, while 27.3% (n=8) had noninvasive tumor. In addition, there was a significant relationship between invasive thymoma rate and developing myasthenia gravis. The 3-year survival rate for all patients was equivalent to 83.3%. However; 5-year survival was equal to 71%.
Conclusions: According to the study, most patients with invasive thymoma had a 5-year survival rate and also most of them were with myasthenia gravis.


1. Hung AY, Eng TY, Scarbrough TJ, Dave Fuller C, Charles Rand Thomas Jr. Mediastinum and trachea In: Halprin, Edward C, pe-rez, Carlos A, Brady, Luther w, perez and brady s principles and practice of radiation oncology. 5th edition. philadelphia: hip-pincott, Williams and wilkins. 2008; 49:1-39.
2. Kondo K, Kinoshita H, Ishikura H, Miyoshi T, Hirose T, Matsu-mori Y, et al. Activation of matrix metalloproteinase‐2 is correlat-ed with invasiveness in thymic epithelial tumors. J Surgical Oncol. 2001; 76(3): 169-175.
3. Willcox N, Schluep M, Ritter A, Schuan JH, Newsom-Davis J, Chris-tensson B. Myasthenic and non myasthenic thymoma .AR expan-sion of minor cortical epithelial cell. Am J Pathol. Japanese and cross medical center. 2008; 58(8):489-493.
4. Keditsu KK, Karimundackal G, Jambhekar NA, Pramesh CS. Unu-sual clinical behavior of thymoma with recurrent myasthenia gravis. Interact Cardiovasc Thorac Surg. 2012; 14(6): 909-911.
5. Gommes DR, Fuller CD, Chennupati S, Charles R, Thomas Jr. Mediastinal and trachea in Halprin, Edward C, perez, carlos A, Brady Luther W, perez and Brady s principles and practice of radi-ation oncology 6th edition. philadelphia: Lippincott Williams & wilkins. 2013; 52:977-984.
6. Engels EA, Pfeiffer RM. Malignant thymoma in the United States: demographic patterns in incidence and associations with subse-quent malignancies. Int J Cancer. 2003; 105(4): 546-551.
7. Mao ZF, Mo XA, Qin C, Lai YR, Hackett ML. Incidence of thymoma in myasthenia gravis: a systematic review. Journal of Clinical Neu-rology. 2012; 8(3): 161-169.
8. McCart JA, Gaspar L, Inculet R, Casson AG. Predictors of survival following surgical resection of thymoma. Eur J Surg Oncol. 1993; 54(4):233-238.
9. Wilkins KB, Sheikh E, Green R, Patel M, George S, Takan M, et al. Clinical and pathologic predictors of survival in patients with thymoma. Ann Surg. 1999; 230(4): 562.
10. Margaritora S, Cesario A, Cusumano G, Meacci E, D'Angelillo R, Bonassi S, et al. Thirty-five–year follow-up analysis of clinical and pathologic outcomes of thymoma surgery. Ann Thorac Surg. 2010; 89(1):245-252.
11. Nakagawa K, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, et al. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardi-ovasc Surg. 2003; 126(4): 1134-1140.
12. Singhal BS, Bhatia NS, Umesh T, Menon S. A study from india in department of neurology bombey hospital institute of medical science. Neurol India. 2008; 56(3):352-5
13. Aysal F, Baybas S, Selçuk HH, Sozmen V, Ozturk M, Kucukoglu H, et al. Paraneoplastic extralimbic encephalitis associated with thymoma and myastenia gravis: Three years follow up. Clin Neu-rol Neurosurg. 2013; 115(5): 628-631.